Champions Manchester City will travel to Arsenal on the weekend of 11-12 August for their opening match of the 2018-19 Premier League season.
Tottenham visit Newcastle first, then play Fulham at Wembley while their new £850m stadium is completed.
Manchester United host Leicester City, Liverpool entertain West Ham, and Championship winners Wolverhampton Wanderers welcome Everton to Molineux.
Promoted Fulham host Crystal Palace, while Cardiff visit Bournemouth.
The three other fixtures on the opening weekend see Chelsea travel to Huddersfield, Southampton host Burnley, and Watford take on Brighton at Vicarage Road.
Here are the Round 1 fixtures in full:
Arsenal vs. Manchester City
Bournemouth vs. Cardiff City
Fulham vs. Crystal Palace
Huddersfield Town vs. Chelsea
Liverpool vs. West Ham United
Manchester United vs. Leicester City
Newcastle United vs. Tottenham Hotspur
Southampton vs. Burnley
Watford vs. Brighton & Hove Albion
Wolverhampton Wanderers vs. Everton