The sequel of Marvel’s Doctor Strange has lost its director Scott Derrickson.

Derrickson announced on Twitter that he and the studio “mutually agreed to part ways” on the “Doctor Strange” sequel “due to creative differences” but that he will remain an executive producer.

Slated for release in May 2021, Doctor Strange was among the titles announced as part of Marvel’s Phase 4 during the studio’s San Diego Comic-Con presentation in July.

At the time, Marvel Studios’ Kevin Feige touted the title as the first scary Marvel Cinematic Universe film (while retaining its PG-13 rating).

In a statement, Marvel Studios confirmed that the two parties had “amicably parted ways … due to creative differences.”

“We remain grateful to Scott for his contributions to the MCU,” said Marvel.

Derrickson directed and co-wrote 2016’s “Doctor Strange,” which introduced the once-arrogant neurosurgeon turned Sorcerer Supreme, Dr. Stephen Strange, to the Marvel Cinematic Universe. Played by Benedict Cumberbatch, the character has since appeared in “Thor: Ragnarok” (2017), “Avengers: Infinity War” (2018) and “Avengers: Endgame” (2019).